Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470516 | 0.87 | GPR119 (0.41) | GPR119GPR183KCNH2NTRK1ACACB | |
| SCHEMBL470490 | 0.86 | GPR119 (0.40) | GPR119GPR183RBP4TTRKCNH2 | |
| SCHEMBL470479 | 0.85 | GPR119 (0.36) | GPR119KCNH2NTRK1 | |
| SCHEMBL12064975 | 0.84 | GPR119 (0.39) | GPR119GPR183KCNH2NTRK1 | |
| SCHEMBL12064792 | 0.84 | GPR119 (0.45) | GPR119GPR183KCNH2ACACB | |
| SCHEMBL470743 | 0.84 | GPR119 (0.36) | GPR119GPR183KCNH2NTRK1 | |
| SCHEMBL149964 | 0.83 | GPR119 (0.38) | GPR119GPR183KCNH2NTRK1 | |
| SCHEMBL149962 | 0.83 | GPR119 (0.38) | GPR119GPR183KCNH2NTRK1 | |
| SCHEMBL470525 | 0.83 | GPR119 (0.36) | GPR119GPR183KCNH2NTRK1 | |
| SCHEMBL149963 | 0.83 | GPR119 (0.38) | GPR119GPR183KCNH2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |