Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702854 | 0.82 | CHKA (0.50) | HRH3DRD2DRD3 | |
| SCHEMBL4703341 | 0.81 | CYP2D6 (0.50) | MBTD1L3MBTL3L3MBTL1HRH3ACHE | |
| SCHEMBL18155147 | 0.81 | MBTD1 (0.49) | MBTD1L3MBTL3L3MBTL1HRH3ACHE | |
| SCHEMBL15037944 | 0.79 | DPP4 (0.60) | MBTD1L3MBTL3L3MBTL1HRH3SLC6A2 | |
| SCHEMBL2095327 | 0.79 | SLC6A2 (0.47) | MBTD1L3MBTL3L3MBTL1HRH3ACHE | |
| SCHEMBL3389633 | 0.79 | CYP2D6 (0.56) | MBTD1L3MBTL3L3MBTL1HRH3ACHE | |
| SCHEMBL19820168 | 0.77 | DPP4 (0.55) | MBTD1L3MBTL3L3MBTL1HRH3SLC6A2 | |
| SCHEMBL22837815 | 0.77 | CHRM4 (0.52) | MBTD1L3MBTL3L3MBTL1HRH3ACHE | |
| SCHEMBL718248 | 0.77 | BPTF (0.53) | MBTD1L3MBTL3L3MBTL1HRH3ACHE | |
| SCHEMBL31175219 | 0.77 | MBTD1 (0.52) | MBTD1L3MBTL3L3MBTL1HRH3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | claimed |
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | disclosed |