Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.35 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.35 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470632 | 0.85 | GPR119 (0.58) | GPR119GPR183ACACBABCB1ABCC1 | |
| SCHEMBL12064582 | 0.83 | GPR119 (0.40) | GPR119GPR183ACACB | |
| SCHEMBL462956 | 0.82 | DPP4 (0.39) | GPR119GPR183KCNH2 | |
| SCHEMBL462923 | 0.72 | GPR119 (0.40) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL461048 | 0.72 | HTR2C (0.41) | GPR119 | |
| SCHEMBL13186518 | 0.71 | GPR119 (0.44) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL470661 | 0.71 | GPR119 (0.47) | GPR119GPR183ACACBKCNH2CAMK1D | |
| SCHEMBL461135 | 0.70 | GPR119 (0.61) | GPR119GPR183ABCB1ABCC1ABCG2 | |
| SCHEMBL470700 | 0.69 | GPR119 (0.53) | GPR119GPR183ACACBABCB1ABCC1 | |
| SCHEMBL470613 | 0.68 | GPR119 (0.49) | GPR119GPR183KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |