Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL461048 | 0.82 | HTR2C (0.41) | GPR119CHRM4EPHX2SMN1; SMN2 | |
| SCHEMBL388551 | 0.79 | GPR119 (0.59) | GPR119GPR183KCNH2 | |
| SCHEMBL470574 | 0.72 | GPR119 (0.45) | GPR119GPR183KCNH2ABCB1ABCC1 | |
| SCHEMBL462444 | 0.70 | GPR119 (0.39) | GPR119GPR183KCNH2 | |
| SCHEMBL3321087 | 0.69 | F10 (0.40) | GPR119EPHX2MAPT | |
| SCHEMBL3533847 | 0.69 | ALDH1A1 (0.35) | GPR119 | |
| SCHEMBL384560 | 0.69 | GPR119 (0.55) | GPR119 | |
| SCHEMBL148647 | 0.69 | GPR119 (0.55) | GPR119GPR183KCNH2 | |
| SCHEMBL8549864 | 0.69 | ACHE (0.56) | SMN1; SMN2 | |
| SCHEMBL20323516 | 0.69 | MAPT (0.48) | GPR119MAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |