Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.34 |
| ▸ | ICMT | O60725 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225032 | 0.82 | HSD17B10 (0.42) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL6180348 | 0.82 | GABRA1 (0.36) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL1477497 | 0.78 | SETDB1 (0.43) | HTT | |
| SCHEMBL3837338 | 0.78 | ALDH1A1 (0.38) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL15524127 | 0.77 | ICMT (0.39) | MAPK8ICMTHTT | |
| SCHEMBL18097560 | 0.77 | FFAR1 (0.34) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL6557230 | 0.76 | SMN1; SMN2 (0.39) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL1115079 | 0.74 | MAPK8 (0.52) | MAPK8ICMT | |
| SCHEMBL28027717 | 0.74 | GRM5 (0.39) | MAPK8FFAR1 | |
| SCHEMBL1476652 | 0.73 | IKBKB (0.37) | GABRA1GABRA5GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971606-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-09-24 | — | — | EP | disclosed |
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2007067506-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |