SCHEMBL470588

SCHEMBL470588

CC(C)OC(=O)N1CCC([C@H](C)Oc2cnc(N3CC[C@@H](N)C3)nc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 17/20 0.46
ACACB O00763 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL470657 0.89 ACACB (0.43) ACACB
SCHEMBL13186861 0.86 GPR119 (0.48) GPR119ACACB
SCHEMBL470687 0.82 GPR119 (0.39) GPR119ACACB
SCHEMBL470599 0.80 GPR119 (0.43) GPR119ACACB
SCHEMBL470453 0.79 GPR119 (0.47) GPR119
SCHEMBL470748 0.79 GPR119 (0.47) GPR119
SCHEMBL462389 0.77 MCHR1 (0.41) GPR119
Hydrochloric Acid SCHEMBL462388 0.76 MCHR1 (0.40) GPR119
SCHEMBL470661 0.74 GPR119 (0.47) GPR119ACACB
SCHEMBL470585 0.73 GPR119 (0.35) GPR119ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011147951-A1 CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS PROSIDION LIMITED (GB) 2011-12-01 WO disclosed