Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470605 | 0.86 | PDE10A (0.43) | CKS1BSKP1SKP2PDE10AJAK3 | |
| SCHEMBL470541 | 0.86 | L3MBTL1 (0.46) | GPR119CKS1BSKP1SKP2HSD11B1 | |
| SCHEMBL12064784 | 0.83 | GPR119 (0.43) | GPR119CKS1BSKP1SKP2PDE10A | |
| SCHEMBL470588 | 0.80 | GPR119 (0.46) | GPR119ACACB | |
| SCHEMBL1063091 | 0.77 | EPHX1 (0.55) | HSD11B1CYP2C9BTKCTSK | |
| SCHEMBL15191231 | 0.76 | MAP4K4 (0.50) | CKS1BSKP1SKP2PDE10AJAK3 | |
| SCHEMBL31271961 | 0.76 | PDE10A (0.50) | CKS1BSKP1SKP2HSD11B1CYP2C9 | |
| SCHEMBL951253 | 0.76 | PDE10A (0.50) | CKS1BSKP1SKP2HSD11B1CYP2C9 | |
| SCHEMBL951251 | 0.76 | PDE10A (0.50) | CKS1BSKP1SKP2HSD11B1CYP2C9 | |
| SCHEMBL31038865 | 0.76 | PDE10A (0.50) | CKS1BSKP1SKP2HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |