Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759295 | 0.88 | POLB (0.37) | HSP90AA1HSP90AB1POLBGRIN1GRIN2B | |
| SCHEMBL4706975 | 0.88 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1POLBGRIN1GRIN2B | |
| SCHEMBL4638838 | 0.86 | POLB (0.38) | HSP90AA1HSP90AB1POLBHTTL3MBTL1 | |
| SCHEMBL4707593 | 0.83 | P2RX7 (0.36) | HSP90AA1HSP90AB1GABRA2GABRB2 | |
| SCHEMBL4707683 | 0.81 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1POLBHTTL3MBTL1 | |
| SCHEMBL4708507 | 0.79 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1POLBL3MBTL1CYP1A2 | |
| SCHEMBL4708592 | 0.78 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1POLBGABRA2GABRB2 | |
| SCHEMBL4708607 | 0.77 | GABRA2 (0.35) | HSP90AA1HSP90AB1GABRA2GABRB2 | |
| SCHEMBL3673183 | 0.76 | CDC7 (0.48) | — | |
| SCHEMBL4804309 | 0.73 | PAX8 (0.35) | HSP90AA1HSP90AB1POLBGABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |