Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470599 | 0.86 | GPR119 (0.43) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL12064784 | 0.82 | GPR119 (0.43) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL470541 | 0.80 | L3MBTL1 (0.46) | CKS1BSKP1SKP2CTSK | |
| SCHEMBL951251 | 0.78 | PDE10A (0.50) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL31038865 | 0.78 | PDE10A (0.50) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL31271961 | 0.78 | PDE10A (0.50) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL951253 | 0.78 | PDE10A (0.50) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL15191231 | 0.78 | MAP4K4 (0.50) | PDE10ACKS1BSKP1SKP2BTK | |
| SCHEMBL458009 | 0.78 | DPP4 (0.35) | ACACB | |
| SCHEMBL18239342 | 0.77 | GPR119 (0.55) | PDE10ACKS1BSKP1SKP2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |