Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 12/20 | 0.46 |
| ▸ | KDM1B | Q8NB78 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 6/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941500 | 1.00 | CHRNB2 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL179110 | 0.80 | KDM1A (0.66) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL13186510 | 0.80 | HTR2C (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL12064742 | 0.79 | HTR2C (0.46) | CHRNB2CHRNA4KDM1AKDM1BKCNH2 | |
| SCHEMBL15072097 | 0.77 | KDM1A (0.70) | KDM1AKDM1BKCNH2DPP4DPP8 | |
| SCHEMBL3446487 | 0.77 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL179045 | 0.76 | KDM1A (0.63) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL12499210 | 0.74 | HTR2A (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL16649443 | 0.74 | HTR2A (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A | |
| SCHEMBL461043 | 0.74 | HTR2C (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010103334-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |