SCHEMBL470641

CCOC(=O)c1coc(N2CCC([C@H](C)Oc3cnc(N4C[C@H](NC(=O)OC(C)(C)C)[C@@H](c5cc(F)ccc5F)C4)nc3)CC2)n1

nearest known ligand 0.34

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	NTRK1	P04629	4/20	0.34

▸	RET	P07949	7/20	0.33

▸	NR1H2	P55055	6/20	0.33

▸	NR1H3	Q13133	5/20	0.33

▸	DPP4	P27487	1/20	0.33

▸	DPP8	Q6V1X1	1/20	0.33

▸	DPP9	Q86TI2	1/20	0.33

▸	DPP7	Q9UHL4	1/20	0.33

▸	GPR119	Q8TDV5	1/20	0.32

▸	MAP3K5	Q99683	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL462819	0.89	NTRK1 (0.34)	NTRK1RETNR1H2NR1H3DPP4
SCHEMBL470523	0.84	NTRK1 (0.35)	NTRK1RETNR1H2GPR119
SCHEMBL12064744	0.83	NTRK1 (0.34)	NTRK1RETNR1H2GPR119
SCHEMBL470608	0.82	NTRK1 (0.37)	NTRK1RETNR1H2GPR119MAP3K5
SCHEMBL12064739	0.82	NTRK1 (0.35)	NTRK1RETNR1H2GPR119MAP3K5
SCHEMBL12064745	0.82	NTRK1 (0.34)	NTRK1RETNR1H2GPR119
SCHEMBL460032	0.82	NTRK1 (0.38)	NTRK1RET
SCHEMBL470601	0.82	NTRK1 (0.38)	NTRK1RETNR1H2
SCHEMBL470486	0.81	NTRK1 (0.36)	NTRK1RETNR1H2GPR119
SCHEMBL461775	0.81	OPRK1 (0.31)	RETNR1H2NR1H3MAP3K5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011147951-A1	CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS	PROSIDION LIMITED (GB)	2011-12-01	—	—	WO	disclosed