Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 13/20 | 0.54 |
| ▸ | PGR | P06401 | 8/20 | 0.54 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704555 | 0.87 | NR3C1 (0.51) | NR3C1PGRPTGER1PTGER4PTGER3 | |
| SCHEMBL4703771 | 0.86 | NR3C1 (0.50) | NR3C1PGRPTGER1PTGER4PTGER3 | |
| SCHEMBL4706734 | 0.85 | NR3C1 (0.60) | NR3C1PGRPTGER1PTGER4PTGER3 | |
| SCHEMBL4704793 | 0.85 | NR3C1 (0.68) | NR3C1PGR | |
| SCHEMBL4702719 | 0.85 | PGR (0.55) | NR3C1PGRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4706288 | 0.84 | NR3C1 (0.48) | NR3C1PGRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4702596 | 0.84 | NR3C1 (0.61) | NR3C1PGR | |
| SCHEMBL4705677 | 0.83 | NR3C1 (0.71) | NR3C1PGRPTGER1PTGER4PTGER3 | |
| SCHEMBL4702888 | 0.82 | NR3C1 (0.62) | NR3C1PGR | |
| SCHEMBL4706194 | 0.82 | PGR (0.55) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532113-B1 | SUBSTITUTED HIHYDROQUINOLINES AS GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMA (US) | 2008-08-06 | — | — | EP | claimed |