Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 13/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706431 | 0.85 | NR3C1 (0.54) | PGRNR3C1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4705889 | 0.84 | PGR (0.67) | PGRNR3C1L3MBTL1 | |
| SCHEMBL4702992 | 0.84 | PGR (0.57) | PGRNR3C1 | |
| SCHEMBL4706734 | 0.81 | NR3C1 (0.60) | PGRNR3C1L3MBTL1 | |
| SCHEMBL4706194 | 0.79 | PGR (0.55) | PGRNR3C1 | |
| SCHEMBL4702596 | 0.79 | NR3C1 (0.61) | PGRNR3C1 | |
| SCHEMBL4702715 | 0.77 | PGR (0.74) | PGRNR3C1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4704555 | 0.77 | NR3C1 (0.51) | PGRNR3C1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4705877 | 0.77 | PGR (0.58) | PGRNR3C1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4704987 | 0.76 | PGR (0.57) | PGRNR3C1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532113-B1 | SUBSTITUTED HIHYDROQUINOLINES AS GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMA (US) | 2008-08-06 | — | — | EP | claimed |