Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064798 | 0.85 | GPR119 (0.40) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470672 | 0.85 | ACACB (0.35) | — | |
| SCHEMBL12064851 | 0.80 | GPR119 (0.35) | GPR119GPR183KCNH2 | |
| SCHEMBL12064539 | 0.80 | GPR119 (0.35) | GPR119GPR183KCNH2 | |
| SCHEMBL12064555 | 0.80 | GPR119 (0.35) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470549 | 0.79 | ALOX5AP (0.30) | — | |
| SCHEMBL470627 | 0.79 | GPR119 (0.44) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470864 | 0.79 | GPR119 (0.30) | GPR119 | |
| SCHEMBL470661 | 0.77 | GPR119 (0.47) | GPR119GPR183KCNH2CYP2C19 | |
| SCHEMBL470626 | 0.76 | GPR119 (0.49) | GPR119GPR183KCNH2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |