SCHEMBL470549

SCHEMBL470549

C[C@H](Oc1cnc(N2C[C@H](NC(=O)OC(C)(C)C)[C@@H](C3=CC(F)C(F)C=C3F)C2)nc1)C1CCN(c2nc(C(C)(C)O)no2)CC1

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.30
CKS1B P61024 1/20 0.30
SKP1 P63208 1/20 0.30
SKP2 Q13309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL470523 0.86 NTRK1 (0.35) ALOX5APCKS1BSKP1SKP2
SCHEMBL12064814 0.85 NR1H2 (0.33) ALOX5APCKS1BSKP1SKP2
SCHEMBL12064539 0.84 GPR119 (0.35)
SCHEMBL470647 0.83 CKS1B (0.32) CKS1BSKP1SKP2
SCHEMBL470798 0.83 DPP4 (0.32) ALOX5AP
SCHEMBL12064745 0.81 NTRK1 (0.34) ALOX5AP
SCHEMBL12064744 0.81 NTRK1 (0.34) ALOX5AP
SCHEMBL12064985 0.80 DPP4 (0.33) CKS1BSKP1SKP2
SCHEMBL470659 0.79 GPR119 (0.39)
SCHEMBL470690 0.78 ALOX5AP (0.32) ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011147951-A1 CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS PROSIDION LIMITED (GB) 2011-12-01 WO disclosed