Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707143 | 1.00 | MEN1 (0.35) | MEN1KMT2AHPGDNPSR1GPR84 | |
| SCHEMBL5133396 | 0.75 | MAOA (0.41) | MEN1KMT2ACHRM2HTR1AADRA2A | |
| SCHEMBL4708551 | 0.74 | S100A4 (0.42) | MEN1KMT2AHPGDCHRM2HTR1A | |
| SCHEMBL11704742 | 0.63 | MAOA (0.34) | MEN1KMT2ACHRM2HTR1AADRA2A | |
| SCHEMBL11588872 | 0.63 | ALDH1A1 (0.41) | MEN1KMT2AHPGDCHRM2HTR1A | |
| SCHEMBL5266267 | 0.63 | MAOA (0.46) | MEN1KMT2ACHRM2HTR1AADRA2A | |
| SCHEMBL904813 | 0.63 | MAOA (0.41) | MEN1KMT2ACHRM2HTR1AADRA2A | |
| SCHEMBL10866375 | 0.63 | MAOA (0.31) | HPGDALDH1A1 | |
| SCHEMBL29697456 | 0.63 | MAOA (0.46) | MEN1KMT2ACHRM2HTR1AADRA2A | |
| SCHEMBL19537629 | 0.61 | ALDH1A1 (0.48) | MEN1KMT2AHPGDNPSR1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687314-B1 | PREPARATION OF 1-AZA-2-OXA-DIBENZO [e,h] AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS | GLAXOSMITHKLINE ZAGREB (HR) | 2008-12-24 | — | — | EP | disclosed |
| US-20070078124-A1 | 1-Aza-2-oxa-dibenzo(e,h)azulenes and their use for the treatment of central nervous system diseases and disorders | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078124-A1 | 1-Aza-2-oxa-dibenzo(e,h)azulenes and their use for the treatment of central nervous system diseases and disorders | DBH, AZI2, MAOB | MEN1 1279/4885KMT2A 928/4885HPGD 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.