Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708847 | 0.95 | HTT (0.46) | HTTHSD17B10MCL1KMT2AMEN1 | |
| SCHEMBL4706833 | 0.94 | MCL1 (0.46) | HTTHSD17B10MCL1KDM4ENPC1 | |
| SCHEMBL4775162 | 0.90 | MCL1 (0.39) | HTTHSD17B10MCL1KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL4516276 | 0.87 | MCL1 (0.49) | HTTHSD17B10MCL1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL4520019 | 0.86 | MCL1 (0.46) | HTTHSD17B10MCL1KDM4EKMT2A | |
| SCHEMBL4778114 | 0.83 | KDM4E (0.42) | HTTMCL1KDM4ENPC1RAB9A | |
| SCHEMBL4778117 | 0.83 | KDM4E (0.42) | HTTMCL1KDM4ENPC1RAB9A | |
| SCHEMBL4708555 | 0.82 | DRD2 (0.40) | MCL1KDM4ENPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL4527694 | 0.81 | MCL1 (0.58) | HTTHSD17B10MCL1KDM4EALDH1A1 | |
| SCHEMBL4706258 | 0.81 | ALDH1A1 (0.47) | HTTHSD17B10MCL1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | claimed |
| EP-1873150-A1 | Fluorinated indoleamides useful as ligands of the ORL-1 receptor | NIKEM RESEARCH S.R.L. (IT) | 2008-01-02 | — | — | EP | claimed |
| WO-2008000818-A1 | FLUORINATED INDOLEAMIDES USEFUL AS LIGANDS OF THE ORL-1 RECEPTOR | BRANE DISCOVERY S.R.L. (IT) | 2008-01-03 | — | — | WO | disclosed |
| EP-1873150-A1 | Fluorinated indoleamides useful as ligands of the ORL-1 receptor | NIKEM RESEARCH S.R.L. (IT) | 2008-01-02 | — | — | EP | disclosed |