Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706503 | 0.92 | P2RX7 (0.37) | P2RX7GALR3NR2F2SMN1; SMN2MAPT | |
| SCHEMBL4705865 | 0.90 | ALDH1A1 (0.42) | SMN1; SMN2HRH4LMNAMETTACR1 | |
| SCHEMBL4705490 | 0.83 | P2RX7 (0.36) | P2RX7GRM2SMN1; SMN2MAPTLMNA | |
| SCHEMBL4706989 | 0.82 | P2RX7 (0.36) | P2RX7GALR3NR2F2GRM2SMN1; SMN2 | |
| SCHEMBL4707128 | 0.82 | ALDH1A1 (0.42) | SMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL4707246 | 0.81 | RAF1 (0.35) | P2RX7 | |
| SCHEMBL4709715 | 0.81 | CDC7 (0.43) | P2RX7GRM2MAPK1SMN1; SMN2NR1I2 | |
| SCHEMBL4707457 | 0.81 | CDC7 (0.42) | P2RX7GRM2MAPK1LMNANR1I2 | |
| SCHEMBL4709868 | 0.80 | P2RX7 (0.35) | P2RX7GALR3NR2F2GRM2SMN1; SMN2 | |
| SCHEMBL4705300 | 0.80 | ALDH1A1 (0.40) | SMN1; SMN2LMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |