Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.36 |
| ▸ | RORB | Q92753 | 5/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.32 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707988 | 1.00 | PTGER4 (0.36) | PTGER4RORBRORCTACR1AKR1C3 | |
| SCHEMBL4708475 | 0.90 | RORB (0.37) | PTGER4RORBRORCTACR1AKR1C3 | |
| SCHEMBL4708474 | 0.90 | RORB (0.37) | PTGER4RORBRORCTACR1AKR1C3 | |
| SCHEMBL4705104 | 0.88 | POLB (0.35) | PTGER4KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4637886 | 0.85 | EPAS1 (0.39) | PTGER4TACR1KMT2ANR1H4KDM4E | |
| SCHEMBL4705694 | 0.85 | LMNA (0.43) | RORBRORCTACR1KMT2A | |
| SCHEMBL4708267 | 0.83 | RORB (0.38) | RORBRORCTACR1AKR1C3KMT2A | |
| SCHEMBL4638837 | 0.78 | ALDH1A1 (0.38) | TACR1KMT2ANR1H4HTTSMN1; SMN2 | |
| SCHEMBL4707456 | 0.78 | POLB (0.37) | RORCTACR1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4707455 | 0.78 | POLB (0.37) | RORCTACR1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |