Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 10/20 | 0.42 |
| ▸ | RORC | P51449 | 5/20 | 0.42 |
| ▸ | TACR1 | P25103 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705884 | 0.89 | RORB (0.40) | RORBRORCTACR1TP53MAPT | |
| SCHEMBL4708328 | 0.89 | RORB (0.41) | RORBRORCTACR1TP53MAPT | |
| SCHEMBL4705450 | 0.88 | RORB (0.42) | RORBRORCCDC7PLK4MAPK13 | |
| SCHEMBL4705403 | 0.86 | RORB (0.41) | RORBRORCCDC7MAPK1 | |
| SCHEMBL4706766 | 0.86 | RORB (0.43) | RORBRORCTACR1CDC7HTT | |
| SCHEMBL4705502 | 0.85 | RORB (0.39) | RORBRORCTACR1MAPTSMN1; SMN2 | |
| SCHEMBL6389497 | 0.85 | IDH1 (0.42) | RORBRORCCDC7GABRA2GABRB2 | |
| SCHEMBL4705655 | 0.84 | AKT1 (0.39) | RORBRORCSMN1; SMN2 | |
| SCHEMBL4759328 | 0.82 | RORB (0.43) | RORBRORCTACR1SMN1; SMN2GAA | |
| SCHEMBL4707181 | 0.82 | RORB (0.40) | RORBRORCTACR1MAPTCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |