Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 10/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759328 | 0.90 | RORB (0.43) | RORBRORCTACR1KDM4EHTT | |
| SCHEMBL4707181 | 0.88 | RORB (0.40) | RORBRORCTACR1KDM4EHTT | |
| SCHEMBL4707650 | 0.88 | RORB (0.41) | RORBRORCGAAPTGER4GRM2 | |
| SCHEMBL4708209 | 0.86 | RORB (0.39) | RORBRORCTACR1GRM2 | |
| SCHEMBL4705184 | 0.86 | TACR1 (0.44) | RORBRORCTACR1 | |
| SCHEMBL4708293 | 0.85 | RORB (0.40) | RORBRORCTACR1GAAP2RX7 | |
| SCHEMBL4708522 | 0.85 | RORB (0.42) | RORBRORCTACR1KDM4EHTT | |
| SCHEMBL4707133 | 0.85 | RORB (0.40) | RORBRORCTACR1HTTGRM2 | |
| SCHEMBL4705371 | 0.84 | IDH1 (0.43) | RORBRORCGAAGRM2 | |
| SCHEMBL4706528 | 0.83 | RORB (0.36) | RORBRORCTACR1P2RX7GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |