Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711486 | 0.89 | GRM5 (0.46) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL4713871 | 0.85 | GRM5 (0.42) | GRM5 | |
| SCHEMBL4711597 | 0.83 | GRM5 (0.44) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL4712463 | 0.79 | GRM5 (0.49) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL4713592 | 0.77 | GRM5 (0.44) | GRM5 | |
| SCHEMBL4710432 | 0.69 | GRM5 (0.53) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL6615172 | 0.67 | RAB9A (0.44) | KDM4EALDH1A1TP53CYP1A2CYP2C9 | |
| SCHEMBL4710493 | 0.65 | GRM5 (0.60) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL4712241 | 0.64 | GRM5 (0.67) | GRM5KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL4711689 | 0.64 | GRM5 (0.66) | GRM5KDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |