Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711597 | 0.88 | GRM5 (0.44) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4713592 | 0.86 | GRM5 (0.44) | GRM5 | |
| SCHEMBL4711486 | 0.84 | GRM5 (0.46) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4711268 | 0.79 | GRM5 (0.43) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4713871 | 0.79 | GRM5 (0.42) | GRM5 | |
| SCHEMBL20594437 | 0.77 | GRM5 (0.54) | GRM5SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL29794847 | 0.77 | GRM5 (0.54) | GRM5SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL15020092 | 0.75 | MEN1 (0.55) | NPC1SMN1; SMN2MEN1ALDH1A1TP53 | |
| SCHEMBL4710432 | 0.74 | GRM5 (0.53) | GRM5NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15019823 | 0.71 | MAPT (0.50) | SMN1; SMN2KDM4EALDH1A1TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |