Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | NRAS | P01111 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 5/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3846948 | 0.99 | FLT3 (0.39) | FLT3NRASCHEK1CHEK2ABL1 | |
| Hydrochloric Acid SCHEMBL3849166 | 0.88 | FLT3 (0.42) | FLT3NRASCHEK1CHEK2ABL1 | |
| SCHEMBL3856718 | 0.87 | NPC1 (0.46) | FLT3NRASKITROCK2ROCK1 | |
| SCHEMBL3846729 | 0.87 | SMN1; SMN2 (0.46) | FLT3NRASCHEK1CHEK2ABL1 | |
| SCHEMBL4713522 | 0.87 | CHEK1 (0.42) | FLT3NRASCHEK1CHEK2ABL1 | |
| Hydrochloric Acid SCHEMBL3847294 | 0.87 | SMN1; SMN2 (0.45) | FLT3NRASCHEK1CHEK2ABL1 | |
| Hydrochloric Acid SCHEMBL5852371 | 0.87 | NPC1 (0.45) | FLT3NRASKITROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL3855591 | 0.86 | CHEK1 (0.41) | FLT3NRASCHEK1CHEK2ABL1 | |
| SCHEMBL4715804 | 0.82 | LOXL2 (0.43) | FLT3NRASCHEK1CHEK2ABL1 | |
| SCHEMBL3846503 | 0.81 | CLK1 (0.37) | MAPK1IKBKBCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | claimed |