Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821977 | 0.90 | MAPT (0.49) | MAPTLMNAMEN1ALOX12KMT2A | |
| SCHEMBL8127278 | 0.88 | MAPT (0.50) | MAPTLMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5085765 | 0.84 | SMN1; SMN2 (0.50) | MAPTLMNASMN1; SMN2FAAHL3MBTL1 | |
| SCHEMBL844472 | 0.84 | SMN1; SMN2 (0.57) | MAPTLMNAALDH1A1SMN1; SMN2FAAH | |
| SCHEMBL14040614 | 0.84 | SMN1; SMN2 (0.57) | MAPTLMNAALDH1A1SMN1; SMN2FAAH | |
| SCHEMBL7050834 | 0.84 | MAPT (0.44) | MAPTLMNAMEN1ALOX12KMT2A | |
| SCHEMBL4683206 | 0.83 | MAPT (0.52) | MAPTLMNAMEN1ALOX12KMT2A | |
| SCHEMBL4097623 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2FAAHL3MBTL1NPC1HPGD | |
| SCHEMBL2320404 | 0.83 | FAAH (0.59) | MAPTLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4265545 | 0.83 | SMN1; SMN2 (0.50) | MAPTLMNAALDH1A1SMN1; SMN2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687305-B1 | 1H-IMIDAZOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-07-09 | — | — | EP | disclosed |
| EP-1791837-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006029862-A1 | SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |