Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711953 | 0.83 | MAPT (0.50) | MAPTLMNAMEN1ALOX12KMT2A | |
| SCHEMBL1553456 | 0.83 | FOLH1 (0.51) | MAPTLMNAKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1461981 | 0.83 | ATM (0.60) | LMNASMN1; SMN2L3MBTL1NPC1HPGD | |
| SCHEMBL11491274 | 0.83 | ATM (0.60) | LMNASMN1; SMN2L3MBTL1NPC1HPGD | |
| SCHEMBL9620074 | 0.83 | ESR1 (0.41) | MAPTLMNAMEN1ALOX12KMT2A | |
| SCHEMBL4685821 | 0.82 | ATM (0.63) | LMNAKMT2ASMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL8698369 | 0.82 | ALDH1A1 (0.47) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4686341 | 0.81 | SMN1; SMN2 (0.60) | LMNASMN1; SMN2L3MBTL1NPC1HPGD | |
| SCHEMBL909810 | 0.81 | CA2 (0.51) | MAPTLMNAMEN1ALOX12KMT2A | |
| SCHEMBL909808 | 0.81 | CA2 (0.51) | MAPTLMNAMEN1ALOX12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989186-A1 | HYDANTOIN BASED KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007096259-A1 | HYDANTOIN BASED KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-30 | — | — | WO | disclosed |