Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 3/20 | 0.37 |
| ▸ | GRM6 | O15303 | 3/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620074 | 0.85 | ESR1 (0.41) | MAPTESR1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL4711953 | 0.84 | MAPT (0.50) | MAPTFAAHSMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL16680263 | 0.78 | ITGB3 (0.45) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL5085765 | 0.77 | SMN1; SMN2 (0.50) | MAPTFAAHSMN1; SMN2NPC1HPGD | |
| SCHEMBL7050830 | 0.77 | ALDH1A1 (0.57) | ALDH1A1 | |
| SCHEMBL5499794 | 0.77 | POLB (0.57) | MAPTFAAHSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL14040614 | 0.77 | SMN1; SMN2 (0.57) | MAPTRXFP1FAAHSMN1; SMN2ALDH1A1 | |
| SCHEMBL844472 | 0.77 | SMN1; SMN2 (0.57) | MAPTRXFP1FAAHSMN1; SMN2ALDH1A1 | |
| SCHEMBL4097623 | 0.76 | SMN1; SMN2 (0.48) | FAAHSMN1; SMN2NPC1HPGDRAB9A | |
| SCHEMBL2320404 | 0.76 | FAAH (0.59) | MAPTRXFP1FAAHSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301474-A2 | TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS | Array Biopharma Inc. (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004412-A2 | TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2002-01-17 | — | — | WO | disclosed |