Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CLPP | Q16740 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3221286 | 0.93 | KDM4E (0.48) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| Fumaric Acid SCHEMBL3221298 | 0.93 | KDM4E (0.48) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL4717253 | 0.88 | HTR6 (0.44) | DRD4SIGMAR1KCNH2 | |
| SCHEMBL3220411 | 0.84 | GNAI3 (0.47) | KDM4EALDH1A1LMNASIGMAR1ACHE | |
| Fumaric Acid SCHEMBL3220938 | 0.82 | HTR1A (0.42) | KDM4EMEN1KMT2AALDH1A1ALOX15 | |
| Fumaric Acid SCHEMBL3220918 | 0.82 | HTR1A (0.42) | KDM4EMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL4718142 | 0.79 | MEN1 (0.59) | MEN1KMT2APOLBSIGMAR1ACHE | |
| SCHEMBL15914294 | 0.78 | MEN1 (0.39) | KDM4EMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL4715042 | 0.78 | GRIN2B (0.42) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL3207059 | 0.77 | KMT2A (0.38) | KDM4EMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917245-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022946-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |