Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RNF4 | P78317 | 1/20 | 0.53 |
| ▸ | F13A1 | P00488 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979481 | 0.84 | HPGD (0.59) | HPGDSMN1; SMN2PGRALDH1A1ALOX12 | |
| SCHEMBL4714552 | 0.84 | PLAU (0.60) | HPGDSMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| Bromide SCHEMBL5450236 | 0.82 | HPGD (0.58) | HPGDSMN1; SMN2PGRALDH1A1ALOX12 | |
| Phenylguanidine SCHEMBL256023 | 0.81 | ALDH1A1 (0.58) | SMN1; SMN2ALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL653550 | 0.81 | ALDH1A1 (0.85) | HPGDSMN1; SMN2PGRALDH1A1ALOX12 | |
| SCHEMBL5528916 | 0.81 | SMN1; SMN2 (0.66) | HPGDSMN1; SMN2PGRALDH1A1TGM2 | |
| Phenylguanidine SCHEMBL4027020 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1CYP3A4CYP2D6KMT2A | |
| Phenylguanidine SCHEMBL29249611 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1CYP3A4CYP2D6KMT2A | |
| Phenylguanidine SCHEMBL11092906 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1CYP3A4CYP2D6KMT2A | |
| Diphenylether SCHEMBL28792708 | 0.79 | LTA4H (0.67) | CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107311937-A | The licochalcone A dihydro amino-metadiazine compound and its synthetic method of one class tool antitumor activity | 陕西科技大学 | 2017-11-03 | — | — | CN | disclosed |
| US-20100331384-A1 | GUANIDINE BASED COMPOUNDS | UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2010-12-30 | — | — | US | disclosed |
| US-20100331384-A1 | GUANIDINE BASED COMPOUNDS | UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA (ES) | 2010-12-30 | — | — | US | disclosed |
| WO-2009080818-A2 | GUANIDINE BASED COMPOUNDS | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331384-A1 | GUANIDINE BASED COMPOUNDS | ADRB2, ADRA2A, ADRA2C | HPGD 1960/4885SMN1; SMN2 1932/4885PGR 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.