Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5629566 | 0.81 | GRM5 (0.42) | HPGDSMN1; SMN2ALDH1A1GAAKDM4E | |
| SCHEMBL14627745 | 0.79 | POLB (0.35) | HTTPOLBHCAR2ALOX15KDM4E | |
| SCHEMBL5211605 | 0.78 | HSD11B1 (0.49) | HTTHPGDSMN1; SMN2ALDH1A1SRD5A2 | |
| SCHEMBL14720788 | 0.77 | SRD5A2 (0.48) | HPGDSRD5A2SRD5A1 | |
| SCHEMBL14720274 | 0.71 | ALDH1A1 (0.39) | HPGDSMN1; SMN2POLBALDH1A1SRD5A2 | |
| SCHEMBL23365279 | 0.71 | SRD5A2 (0.39) | SRD5A2SRD5A1 | |
| SCHEMBL1346266 | 0.70 | SRD5A1 (0.40) | GAASRD5A2SRD5A1 | |
| SCHEMBL901923 | 0.70 | CHRNB2 (0.54) | HTTHPGDSMN1; SMN2POLBHCAR2 | |
| SCHEMBL1013601 | 0.70 | FAAH (0.44) | POLBSRD5A1 | |
| SCHEMBL1346896 | 0.69 | KDM4E (0.33) | POLBALDH1A1GAASRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |