Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3214937 | 0.99 | EGFR (0.38) | EGFRDRD2MAPK1HTR6PDGFRB | |
| SCHEMBL4717086 | 0.85 | SMN1; SMN2 (0.42) | EGFRMAPK1CYP1A2TSHRHSD17B10 | |
| SCHEMBL4714040 | 0.85 | MEN1 (0.41) | CYP1A2CYP2D6CYP3A4CYP2C19ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3198075 | 0.84 | SMN1; SMN2 (0.43) | EGFRMAPK1CYP1A2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL3218715 | 0.84 | MEN1 (0.41) | CYP1A2CYP2D6CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4718399 | 0.79 | MAPK1 (0.51) | MAPK1CYP1A2CYP2D6TSHRCYP3A4 | |
| SCHEMBL4715098 | 0.78 | HPGD (0.42) | PDGFRBPDGFRATSHRTP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3211777 | 0.78 | LMNA (0.42) | MAPK1HTR6TSHRALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3209458 | 0.78 | HPGD (0.41) | PDGFRBPDGFRATSHRTP53ALDH1A1 | |
| SCHEMBL4715918 | 0.78 | MEN1 (0.42) | MAPK1CYP1A2CYP2D6TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917245-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022946-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |