Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4155344 | 0.92 | FASN (0.42) | FASNPDPK1PTGS2CAMKK2TTK | |
| Butyric Acid SCHEMBL4153848 | 0.90 | FASN (0.41) | FASNPDPK1PTGS2CAMKK2TTK | |
| 3-Methylbutanoic Acid SCHEMBL4163003 | 0.88 | FASN (0.40) | FASNPDPK1PTGS2CAMKK2NR1H2 | |
| SCHEMBL4159560 | 0.87 | VCP (0.41) | FASNPDPK1PTGS2CAMKK2 | |
| Propionic Acid SCHEMBL4155190 | 0.81 | PTGS2 (0.40) | PTGS2 | |
| SCHEMBL4713436 | 0.80 | PARP1 (0.46) | PDPK1 | |
| Propionic Acid SCHEMBL4159324 | 0.77 | FASN (0.48) | FASNCAMKK2 | |
| SCHEMBL3242761 | 0.77 | CAMKK2 (0.46) | FASNPDPK1PTGS2CAMKK2 | |
| Propionic Acid SCHEMBL4153840 | 0.77 | PIM1 (0.44) | — | |
| SCHEMBL13951195 | 0.77 | PDPK1 (0.38) | FASNPDPK1PTGS2CAMKK2MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |