Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PPIA | P62937 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273708 | 0.82 | DHODH (0.54) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL5591575 | 0.80 | PPARA (0.47) | LMNAMAPTSMN1; SMN2STAT3HTT | |
| SCHEMBL16015342 | 0.79 | LMNA (0.67) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL4662882 | 0.78 | STAT3 (0.47) | MAPTL3MBTL1SMN1; SMN2DHODHMAPK1 | |
| SCHEMBL18009394 | 0.78 | HPGD (0.55) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL22300744 | 0.77 | LMNA (0.52) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL28448203 | 0.76 | HPGD (0.71) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL2338199 | 0.76 | HPGD (0.76) | LMNAHPGDSMPD1HDAC1HDAC8 | |
| SCHEMBL7619113 | 0.75 | L3MBTL1 (0.54) | LMNAMAPTRAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL15476491 | 0.75 | HPGD (0.65) | LMNAHPGDSMPD1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963311-A1 | CHROMANE SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS ACID PUMP INHIBITORS | Pfizer, Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007072146-A1 | CHROMANE SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS ACID PUMP INHIBITORS | PFIZER JAPAN INC. (JP) | 2007-06-28 | — | — | WO | disclosed |