Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.33 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712642 | 0.91 | BRAF (0.34) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL4714356 | 0.87 | GAPDH (0.34) | GAPDHHSPA1AHSPA8MEN1CYP1A2 | |
| SCHEMBL4712071 | 0.87 | GAPDH (0.34) | GAPDHHSPA1AHSPA8MEN1CYP1A2 | |
| SCHEMBL4712913 | 0.87 | GAPDH (0.34) | GAPDHHSPA1AHSPA8MEN1CYP1A2 | |
| SCHEMBL4712096 | 0.85 | MEN1 (0.36) | GAPDHHSPA1AHSPA8MEN1CYP1A2 | |
| SCHEMBL4713072 | 0.84 | ABCC9 (0.36) | GAPDHHSPA1AHSPA8 | |
| SCHEMBL6823827 | 0.82 | GAPDH (0.34) | GAPDHHSPA1AHSPA8 | |
| SCHEMBL4713720 | 0.79 | GAPDH (0.35) | GAPDHHSPA1AHSPA8MEN1CYP1A2 | |
| SCHEMBL4712218 | 0.79 | GAPDH (0.33) | GAPDHHSPA1AHSPA8MEN1CYP1A2 | |
| SCHEMBL4712640 | 0.77 | HSPA1A (0.43) | GAPDHHSPA1AHSPA8PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412361-B1 | SUBSTITUTED 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2008-07-23 | — | — | EP | claimed |
| EP-1412361-B1 | SUBSTITUTED 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUORENE-6-CARBOXYLIC ACID DERIVATIVES SERVING AS NMDA ANTAGONISTS | GRUENENTHAL GMBH (DE) | 2008-07-23 | — | — | EP | disclosed |