Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 14/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4759102 | 0.77 | BDKRB1 (0.49) | BDKRB1 | |
| SCHEMBL14587787 | 0.73 | LMNA (0.49) | ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A | |
| SCHEMBL1712902 | 0.71 | BDKRB1 (1.00) | CYP3A4CYP1A2CYP2C9CYP2D6HIF1A | |
| SCHEMBL4714849 | 0.70 | CYP2C9 (0.43) | CYP3A4CYP1A2CYP2C9CYP2D6HIF1A | |
| SCHEMBL14587821 | 0.70 | BDKRB1 (0.65) | CYP3A4CYP1A2CYP2C9CYP2D6HIF1A | |
| SCHEMBL4716167 | 0.69 | DRD2 (0.46) | CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL4712012 | 0.69 | CYP3A4 (0.56) | CYP3A4CYP1A2CYP2C9CYP2D6HIF1A | |
| SCHEMBL13151431 | 0.68 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2C9CYP2D6HIF1A | |
| SCHEMBL3096509 | 0.67 | CYP3A4 (0.57) | CYP3A4CYP1A2CYP2C9CYP2D6HIF1A | |
| SCHEMBL25314225 | 0.67 | FASN (0.48) | TSHRALDH1A1SMN1; SMN2MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | ELAN PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | claimed |
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | ELAN PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | disclosed |
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | ELAN PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | disclosed |
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | ELAN PHARMACEUTICALS, INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032475-A1 | Novel compounds useful for bradykinin B1 receptor antagonism | BDKRB1, BDKRB2, NPBWR1 | CYP3A4 3178/4885CYP1A2 2890/4885CYP2C9 3256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.