SCHEMBL4716799

SCHEMBL4716799

O=C1OCCC1=CCNc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
GFER P55789 1/20 0.49
GAA P10253 1/20 0.47
MAPK1 P28482 1/20 0.47
HSP90AA1 P07900 1/20 0.47
HSP90AB1 P08238 1/20 0.47
KDM4E B2RXH2 1/20 0.42
HTT P42858 1/20 0.42
HPGD P15428 4/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
TP53 P04637 1/20 0.41
POLB P06746 1/20 0.41
MAPT P10636 1/20 0.41
DYRK1A Q13627 1/20 0.41
DYRK1B Q9Y463 1/20 0.41
TGM2 P21980 1/20 0.40
RNF4 P78317 1/20 0.40
KMT2A Q03164 2/20 0.39
NAMPT P43490 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10803827 0.87 HSP90AA1 (0.59) ALDH1A1GAAMAPK1HSP90AA1HSP90AB1
SCHEMBL2837762 0.80 HSP90AA1 (0.75) ALDH1A1GFERGAAMAPK1HSP90AA1
SCHEMBL2834565 0.69 ALDH1A1 (0.51) ALDH1A1HTTHPGDNPC1RAB9A
SCHEMBL31497252 0.69 TGM2 (0.56) ALDH1A1GFERGAAHTTHPGD
SCHEMBL1310394 0.64 HSP90AA1 (1.00) ALDH1A1GAAMAPK1HSP90AA1HSP90AB1
SCHEMBL21067997 0.64 HSP90AA1 (1.00) ALDH1A1GAAMAPK1HSP90AA1HSP90AB1
SCHEMBL1310766 0.64 GAA (1.00) ALDH1A1GAAMAPK1HSP90AA1HSP90AB1
SCHEMBL6666527 0.63 LTA4H (0.52) ALDH1A1GFERHPGDRNF4SMN1; SMN2
SCHEMBL709891 0.63 ALDH1A1 (0.64) ALDH1A1GFERGAAHTTHPGD
SCHEMBL5241441 0.63 LTA4H (0.55) ALDH1A1GFERGAAHTTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945211-A1 USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS Helperby Therapeutics Limited (GB) 2008-07-23 EP disclosed
WO-2007054693-A1 USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS HELPERBY THERAPEUTICS LIMITED (GB) 2007-05-18 WO disclosed