Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | CALCA | P06881 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718742 | 0.90 | MC4R (0.45) | MC4RDPP4OPRK1AKT1DPP7 | |
| SCHEMBL3314682 | 0.86 | OPRK1 (0.42) | MC4RDPP4CCR5OPRK1AKT1 | |
| SCHEMBL4722265 | 0.85 | DPP8 (0.47) | OPRK1CALCA | |
| SCHEMBL4722468 | 0.84 | AKT1 (0.43) | MC4ROPRK1AKT1CCR3OPRD1 | |
| SCHEMBL3285190 | 0.77 | OPRK1 (0.44) | DPP4CCR5OPRK1OPRD1HDAC8 | |
| SCHEMBL3279496 | 0.76 | DPP8 (0.49) | OPRK1OPRD1CALCA | |
| SCHEMBL3284873 | 0.75 | L3MBTL3 (0.44) | MC4RDPP4CCR5OPRK1OPRD1 | |
| SCHEMBL4718313 | 0.75 | OPRK1 (0.42) | DPP4CCR5OPRK1DPP7CCR3 | |
| SCHEMBL3314171 | 0.73 | DPP8 (0.47) | OPRK1CALCA | |
| SCHEMBL4717842 | 0.73 | L3MBTL3 (0.41) | DPP4OPRK1AKT1DPP7OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558600-B1 | SELECTED CGRP ANTAGONISTS, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2008-05-07 | — | — | EP | claimed |