Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | BCR | P11274 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718548 | 0.85 | AURKB (0.49) | CSF1RKITFLT3LCKTEK | |
| SCHEMBL4717158 | 0.83 | NLRP3 (0.56) | ANO1LCKTEKABL1BCR | |
| SCHEMBL4718064 | 0.83 | SMN1; SMN2 (0.57) | ANO1CSF1RMAP2K7P2RX4LMNA | |
| SCHEMBL4717797 | 0.82 | MEN1 (0.57) | ANO1LCKTEKABL1BCR | |
| SCHEMBL4716848 | 0.82 | LMNA (0.59) | CSF1RKDRNTRK1EPHX2LMNA | |
| SCHEMBL4720436 | 0.78 | TEK (0.61) | CSF1RKITFLT3LCKTEK | |
| SCHEMBL5253161 | 0.78 | LMNA (0.54) | CSF1RKDRNTRK1EPHX2LMNA | |
| SCHEMBL4717542 | 0.77 | BAZ1A (0.54) | CSF1RKITFLT3LCKTEK | |
| SCHEMBL4719226 | 0.77 | KDR (0.58) | CSF1RKITFLT3LCKTEK | |
| SCHEMBL3666096 | 0.77 | LCK (0.54) | KITLCKTEKKDRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | claimed |