Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 12/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | FLT1 | P17948 | 6/20 | 0.43 |
| ▸ | KIT | P10721 | 5/20 | 0.43 |
| ▸ | TEK | Q02763 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 3/20 | 0.43 |
| ▸ | LYN | P07948 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | BLK | P51451 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719769 | 0.89 | IDH2 (0.55) | IDH2KDRRIPK1FLT1KIT | |
| SCHEMBL4718055 | 0.82 | KDR (0.61) | KDRPDGFRBRIPK1FLT1KIT | |
| SCHEMBL4717542 | 0.78 | BAZ1A (0.54) | KDRRIPK1FLT1KITTEK | |
| SCHEMBL4714365 | 0.78 | LCK (0.65) | IDH2KDRPDGFRBRIPK1TEK | |
| SCHEMBL4720436 | 0.77 | TEK (0.61) | KDRRIPK1FLT1KITTEK | |
| SCHEMBL4875472 | 0.77 | PTK2 (0.56) | IDH2KDRPDGFRBRIPK1FLT1 | |
| SCHEMBL3236450 | 0.75 | RET (0.44) | IDH2KDRPDGFRBRIPK1FLT1 | |
| SCHEMBL27649217 | 0.74 | ADK (0.38) | KDRPDGFRBTEKLCKDYRK1A | |
| SCHEMBL4717817 | 0.74 | RAB9A (0.45) | KDRPDGFRBFLT1KITTEK | |
| SCHEMBL5241624 | 0.73 | RIPK1 (0.50) | IDH2KDRPDGFRBRIPK1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | claimed |
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | TIE1, TEK, TEKT1 | IDH2 740/4885KDR 5/4885PDGFRB 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.