Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.38 |
| ▸ | GSK3B | P49841 | 5/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GNG2 | P59768 | 1/20 | 0.34 |
| ▸ | GNB1 | P62873 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL4171736 | 0.93 | PARP1 (0.41) | PARP1PTPN1GSK3BGRIK1GRIK2 | |
| Propionic Acid SCHEMBL4161934 | 0.80 | KDM4E (0.41) | PARP1GRIK1GRIK2GRIK3CTNNB1 | |
| Propionic Acid SCHEMBL4169905 | 0.78 | KIF11 (0.45) | PARP1GRIK1GRIK2GRIK3KDM4E | |
| SCHEMBL3255989 | 0.76 | PARP1 (0.47) | PARP1PTPN1GRIK1GRIK2GRIK3 | |
| Propionic Acid SCHEMBL4159927 | 0.75 | ALDH1A1 (0.40) | CTNNB1WNT3AKDM4EALDH1A1MEN1 | |
| Propionic Acid SCHEMBL4155436 | 0.74 | PIM3 (0.49) | GSK3BPIM3KDM4EALDH1A1MEN1 | |
| SCHEMBL4715257 | 0.74 | MAPT (0.43) | ALDH1A1MEN1MAPTRAB9AKMT2A | |
| Propionic Acid SCHEMBL4162940 | 0.73 | ALDH1A1 (0.53) | PARP1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL4171728 | 0.73 | PARP1 (0.44) | PARP1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL4716345 | 0.72 | PARP1 (0.58) | PARP1GSK3BPIM3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | disclosed |