Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GNG2 | P59768 | 1/20 | 0.35 |
| ▸ | GNB1 | P62873 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719928 | 0.93 | PARP1 (0.46) | PARP1KDM4EALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4161934 | 0.88 | KDM4E (0.41) | PARP1KDM4EALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4169905 | 0.87 | KIF11 (0.45) | PARP1KDM4EALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4159927 | 0.84 | ALDH1A1 (0.40) | KDM4EALDH1A1MEN1KMT2AHCRTR1 | |
| Propionic Acid SCHEMBL4155436 | 0.83 | PIM3 (0.49) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Propionic Acid SCHEMBL4165125 | 0.81 | PARP1 (0.47) | PARP1KDM4EALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4160624 | 0.81 | MPO (0.43) | KDM4EGSK3BMAPK1 | |
| Propionic Acid SCHEMBL4169911 | 0.81 | GABRA1 (0.41) | PARP1KDM4EALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4162940 | 0.80 | ALDH1A1 (0.53) | PARP1KDM4EALDH1A1MEN1KMT2A | |
| Propionic Acid SCHEMBL4153840 | 0.80 | PIM1 (0.44) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426437-B2 | Pyrroloquinoline derivatives and their use as protein kinases inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2013-04-23 | — | — | US | disclosed |
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042876-A1 | Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors | MAP3K1, MAP3K2, MAP3K7 | PARP1 628/4885KDM4E 1970/4885ALDH1A1 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.