Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | TDP2 | O95551 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25312236 | 0.83 | BRD4 (0.43) | BRD4TDP2ALDH1A1CYP1A2TSHR | |
| SCHEMBL2561503 | 0.82 | L3MBTL1 (0.57) | BRD4ALDH1A1HTTKDM4ETRIM24 | |
| SCHEMBL108857 | 0.80 | BRD4 (0.63) | BRD4TDP2PDE4ACYP1A2TSHR | |
| SCHEMBL29396522 | 0.79 | BRD4 (0.61) | BRD4TDP2PDE4AALDH1A1CYP1A2 | |
| SCHEMBL1240286 | 0.79 | BRD4 (0.61) | BRD4TDP2PDE4AALDH1A1CYP1A2 | |
| SCHEMBL29870373 | 0.79 | BRD4 (0.61) | BRD4TDP2PDE4AALDH1A1CYP1A2 | |
| SCHEMBL28472394 | 0.79 | BRD4 (0.61) | BRD4TDP2PDE4ACYP1A2TSHR | |
| SCHEMBL1737254 | 0.79 | BRD4 (0.61) | BRD4TDP2PDE4AALDH1A1CYP1A2 | |
| SCHEMBL5192649 | 0.78 | TRIM24 (0.42) | ALDH1A1KDM4ETRIM24TRIM33ELANE | |
| SCHEMBL1187172 | 0.78 | BRD4 (0.60) | BRD4TDP2PDE4AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551828-B1 | PYRAZOLE DERIVATIVES | PFIZER LTD (GB) | 2008-01-23 | — | — | EP | disclosed |
| EP-1551828-B1 | PYRAZOLE DERIVATIVES | PFIZER LTD (GB) | 2008-01-23 | — | — | EP | disclosed |
| US-6933312-B2 | Pyrazole derivatives | AGOURON PHARMACEUTICALS, INC. (US) | 2005-08-23 | — | — | US | disclosed |
| EP-1551828-A1 | PYRAZOLE DERIVATIVES | Pfizer Limited (GB) | 2005-07-13 | — | — | EP | disclosed |
| US-20040133002-A1 | Pyrazole derivatives | PFIZER, INC. | 2004-07-08 | — | — | US | disclosed |
| WO-2004031178-A1 | PYRAZOLE DERIVATIVES | PFIZER LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133002-A1 | Pyrazole derivatives | REV1, RRS1, CYP2F1 | BRD4 1051/4885TDP2 1091/4885PDE4A 3351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.