Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 2/20 | 0.34 |
| ▸ | CACNA1A | O00555 | 2/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.34 |
| ▸ | CACNG3 | O60359 | 2/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.34 |
| ▸ | CACNB3 | P54284 | 2/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.34 |
| ▸ | CACNG7 | P62955 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.34 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.34 |
| ▸ | CACNG1 | Q06432 | 2/20 | 0.34 |
| ▸ | CACNB2 | Q08289 | 2/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720846 | 0.90 | GPR119 (0.41) | FLT3CDK2CDK6GPR119S1PR1 | |
| SCHEMBL4720714 | 0.90 | GPR119 (0.40) | FLT3CDK2CDK6GPR119EGFR | |
| SCHEMBL389346 | 0.88 | GPR119 (0.49) | GPR119CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL4719349 | 0.87 | GPR119 (0.46) | FLT3CDK2CDK6GPR119 | |
| SCHEMBL4719099 | 0.87 | GPR119 (0.37) | FLT3CDK2CDK6GPR119S1PR1 | |
| SCHEMBL4722114 | 0.85 | GPR119 (0.38) | FLT3CDK2CDK6GPR119S1PR1 | |
| SCHEMBL4719883 | 0.84 | GPR119 (0.51) | FLT3CDK2CDK6GPR119S1PR1 | |
| SCHEMBL4721923 | 0.84 | GPR119 (0.39) | FLT3CDK2CDK6GPR119KDR | |
| SCHEMBL4765405 | 0.84 | KDR (0.44) | FLT3CDK2CDK6GPR119KDR | |
| SCHEMBL4723304 | 0.83 | GPR119 (0.42) | FLT3CDK2CDK6GPR119KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |