Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4719081 | 0.90 | GPR119 (0.48) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL4721934 | 0.88 | GPR119 (0.51) | GPR119FLT3CDK2CDK6MKNK1 | |
| SCHEMBL4721156 | 0.88 | GPR119 (0.46) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL4719083 | 0.88 | GPR119 (0.56) | GPR119FLT3CDK2CDK6GPR6 | |
| SCHEMBL389783 | 0.88 | GPR119 (0.55) | GPR119 | |
| SCHEMBL4719852 | 0.87 | GPR119 (0.41) | GPR119FLT3CDK2CDK6 | |
| SCHEMBL4723743 | 0.85 | GPR119 (0.52) | GPR119 | |
| SCHEMBL4718480 | 0.85 | GPR119 (0.44) | GPR119FLT3CDK2CDK6CCNT1 | |
| SCHEMBL4723151 | 0.85 | GPR119 (0.44) | GPR119CDK2CDK6CCNT1CCNA2 | |
| SCHEMBL4720846 | 0.84 | GPR119 (0.41) | GPR119FLT3CDK2CDK6KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |