Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.35 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.35 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.35 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.35 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.35 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971629 | 0.86 | PTGS1 (0.43) | GABRA5PTGS2 | |
| SCHEMBL4791287 | 0.83 | FFAR4 (0.47) | FFAR4GABRA5PTGS2CYP1A1CYP1A2 | |
| SCHEMBL4722402 | 0.81 | FFAR4 (0.41) | FFAR4GABRA5PTGS2CYP1A1CYP1A2 | |
| SCHEMBL5744413 | 0.79 | GABRA5 (0.49) | FFAR4GABRA5GPBAR1 | |
| SCHEMBL4761148 | 0.77 | FFAR4 (0.44) | FFAR4GABRA5PTGS2CYP1A2CYP3A4 | |
| SCHEMBL4720864 | 0.75 | LMNA (0.46) | FFAR4GABRA5PTGS2CYP1A1CYP1A2 | |
| SCHEMBL3641902 | 0.74 | FFAR4 (0.50) | FFAR4GABRA5PTGS2GPBAR1 | |
| SCHEMBL4721188 | 0.74 | LMNA (0.51) | FFAR4GABRA5CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL436228 | 0.73 | FFAR4 (0.47) | FFAR4PTGS2CYP1A1CYP1A2CYP2E1 | |
| SCHEMBL4974872 | 0.71 | PTGS2 (0.58) | FFAR4GABRA5PTGS2CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |