Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | PRKX | P51817 | 1/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760730 | 0.85 | AMY1A (0.53) | CBFBAMY1AAURKAKDRPLAU | |
| SCHEMBL2308847 | 0.84 | RAB9A (0.54) | AMY1AKDRGAAKDM4ENPC1 | |
| SCHEMBL2309659 | 0.78 | PDE5A (0.55) | AURKAKDRKDM4ENPC1ALDH1A1 | |
| SCHEMBL2312674 | 0.78 | CBFB (0.51) | CBFBITKAMY1ACHEK1PRKD3 | |
| SCHEMBL4761477 | 0.78 | FGFR1 (0.57) | ITKCHEK1PRKD3PAK4PDGFRA | |
| SCHEMBL2317808 | 0.77 | CBFB (0.50) | CBFBITKAMY1ACHEK1PRKD3 | |
| SCHEMBL2317804 | 0.77 | CBFB (0.50) | CBFBITKAMY1ACHEK1PRKD3 | |
| SCHEMBL12431145 | 0.75 | PDE5A (0.43) | AURKAKDRGAAKDM4ENPC1 | |
| SCHEMBL2314048 | 0.71 | CDK1 (0.42) | CDK5AURKAKDRGAAKDM4E | |
| SCHEMBL4495899 | 0.70 | AMY1A (0.53) | CBFBITKAMY1AKDRPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888579-A2 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | Aventis Pharma S.A. (FR) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006123061-A2 | FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2006-11-23 | — | — | WO | disclosed |