Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722744 | 0.88 | MAPK11 (0.45) | MAPK13MAPK12MAPK11MAPK14CSNK1A1 | |
| SCHEMBL4761505 | 0.84 | MAPK11 (0.52) | JAK2JAK3PTK2ENPP2SMN1; SMN2 | |
| SCHEMBL4025352 | 0.83 | CSNK1A1 (0.60) | HPGDSMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4584849 | 0.83 | CSNK1A1 (0.60) | HPGDSMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8551836 | 0.79 | CSNK1A1 (0.46) | HPGDSMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4790528 | 0.78 | MAPK14 (0.50) | MAPK13MAPK12MAPK11MAPK14CSNK1D | |
| SCHEMBL8549534 | 0.76 | MAPK14 (0.50) | HPGDSJAK2JAK3PTK2ENPP2 | |
| SCHEMBL3099823 | 0.76 | HTT (0.59) | HPGDSMMP13MEN1KMT2AGPR119 | |
| SCHEMBL8554729 | 0.75 | MAPK13 (0.43) | HPGDSJAK2JAK3PTK2MAPK13 | |
| SCHEMBL4762479 | 0.75 | MAPK11 (0.49) | JAK2JAK3PTK2ENPP2MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |