Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4724082 | 0.91 | TBK1 (0.38) | TBK1LCKCDK4ACACBGPR119 | |
| SCHEMBL4718652 | 0.91 | TBK1 (0.39) | TBK1LCKCDK4CDK2ACACB | |
| SCHEMBL391077 | 0.88 | TBK1 (0.47) | TBK1GPR119 | |
| SCHEMBL4719783 | 0.88 | TBK1 (0.39) | TBK1LCKACACBGPR119CACNA1H | |
| SCHEMBL4719875 | 0.88 | MKNK1 (0.39) | TBK1CDK4CDK2ACACBGPR119 | |
| SCHEMBL4763290 | 0.87 | TBK1 (0.40) | TBK1LCKCDK4CDK2ACACB | |
| SCHEMBL4723214 | 0.86 | ERBB2 (0.39) | TBK1LCK | |
| SCHEMBL4723185 | 0.86 | TBK1 (0.38) | TBK1ACACBGPR119KDR | |
| SCHEMBL4722370 | 0.86 | TBK1 (0.39) | TBK1CDK4CDK2ACACBGPR119 | |
| SCHEMBL4723296 | 0.86 | TBK1 (0.39) | TBK1ACACBGPR119CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |