Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 2/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | ACP3 | P15309 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL472186 | 0.87 | SIGMAR1 (0.35) | SIGMAR1ALDH1A1KDM4ETHRBHPGD | |
| SCHEMBL874259 | 0.87 | ALDH1A1 (0.33) | SIGMAR1ALDH1A1KDM4EHSD17B10THRB | |
| SCHEMBL873042 | 0.86 | KDM4E (0.35) | SIGMAR1ALDH1A1KDM4ETHRBHPGD | |
| SCHEMBL472204 | 0.84 | ALDH1A1 (0.36) | SIGMAR1ALDH1A1KDM4ETHRBHPGD | |
| SCHEMBL472191 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDL3MBTL1ACP3 | |
| SCHEMBL7030455 | 0.81 | KDM4E (0.34) | ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL20162548 | 0.81 | KDM4E (0.34) | ALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL874869 | 0.80 | ACP3 (0.39) | ACP3KMT2A | |
| SCHEMBL22341535 | 0.80 | ACP3 (0.39) | ACP3KMT2A | |
| SCHEMBL12496458 | 0.76 | CTSG (0.39) | ALDH1A1KDM4EHPGDL3MBTL1ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412717-A1 | Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus | University College Cardiff Consultants, Ltd. (GB) | 2012-02-01 | — | — | EP | disclosed |
| EP-2097434-B1 | NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS | UNIV CARDIFF (GB) | 2011-06-15 | — | — | EP | disclosed |
| EP-2097434-A2 | NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS | University College Cardiff Consultants Ltd. (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062206-A2 | NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2008-05-29 | — | — | WO | disclosed |