Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 7/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27939112 | 0.92 | FGFR3 (0.44) | FGFR3TBK1ACACBFGFR4FGFR1 | |
| SCHEMBL4722459 | 0.89 | TBK1 (0.38) | FGFR3TBK1ACACBFGFR4FGFR1 | |
| SCHEMBL390655 | 0.88 | TBK1 (0.46) | FGFR3TBK1GPR119PIK3CAPRKDC | |
| SCHEMBL4719368 | 0.85 | TBK1 (0.38) | FGFR3TBK1ACACBFGFR4FGFR1 | |
| SCHEMBL4719783 | 0.85 | TBK1 (0.39) | FGFR3TBK1ACACBCYP3A4CYP2C9 | |
| SCHEMBL4721914 | 0.85 | GPR119 (0.46) | TBK1GPR119S1PR1 | |
| SCHEMBL4723148 | 0.84 | GPR119 (0.41) | FGFR3TBK1ACACBCYP3A4CYP2C9 | |
| SCHEMBL4721012 | 0.84 | TBK1 (0.38) | FGFR3TBK1ACACBFGFR4FGFR1 | |
| SCHEMBL4721883 | 0.84 | CDK1 (0.40) | FGFR3TBK1ACACBEGFRCYP3A4 | |
| SCHEMBL4721660 | 0.84 | GPR119 (0.40) | FGFR3TBK1ACACBCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756084-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2008-11-26 | — | — | EP | claimed |